BIOGENESIS OF CHROMOMYCIN-A3 BY STREPTOMYCES-GRISEUS

被引:28
作者
MONTANARI, A
ROSAZZA, JPN
机构
[1] UNIV IOWA,COLL PHARM,BIOCATALYSIS RES GRP,IOWA CITY,IA 52242
[2] UNIV IOWA,COLL PHARM,DIV MED & NAT PROD CHEM,IOWA CITY,IA 52242
关键词
D O I
10.7164/antibiotics.43.883
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The biosynthesis of chromomycin A3 was investigated using 13C-labeled acetates, methionine and glucose, and 13C, 18O-labeled acetate. 13C NMR spectral analysis demonstrated that: Aglycone assembly occurs by combining at least two polyketide chains; three of nine oxygen atoms of the aglycone originate from acetate precursor oxygen atoms; carbon methylations on the aromatic ring at C-7, on the chromose B sugar, and two O-methylations appear to be carried out by S-adenosyl-methionine requiring methyl transferases; and glucose is the precursor for all of the sugars. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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页码:883 / 889
页数:7
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