REPEATED TREATMENT WITH (-)-SULPIRIDE PLUS A LOW-DOSE OF SCH-23390 DISPLAYS WIDER NEUROLEPTIC ACTIVITY WITHOUT INDUCING DOPAMINERGIC SUPERSENSITIVITY

被引：7

作者：

DALLOLIO, R ^{[1
]}

GANDOLFI, O ^{[1
]}

RONCADA, P ^{[1
]}

VACCHERI, A ^{[1
]}

MONTANARO, N ^{[1
]}

机构：

[1] UNIV BOLOGNA,INST PHARMACOL,VIA IRNERIO 48,I-40126 BOLOGNA,ITALY

来源：

PSYCHOPHARMACOLOGY | 1990年 / 100卷 / 04期

关键词：

(-)-Sulpiride; Apomorphine-induced stereotypy; Dopaminergic supersensitivity; Rat; Repeated treatment; SCH; 23390;

D O I：

10.1007/BF02244013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Combined treatment with (-)-sulpiride plus a low dose of the D1 receptor antagonist SCH 23390, unlike (-)-sulpiride given alone, blocked rat striatal dopaminergic transmission. Five days after the withdrawal of 21-day repeated administration of the combined treatment, no increase in apomorphine-induced stereotyped behaviour was observed. The results suggest that the combination of a D2 blocker and a low dose of a D1 blocker produces a wider spectrum of neuroleptic activity without an overt risk of inducing dopaminergic behavioural supersensitivity. © 1990 Springer-Verlag.

引用

页码：560 / 562

页数：3

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