SELF-STIMULATION OF THE SULCAL PREFRONTAL CORTEX IN THE RAT - DIRECT EVIDENCE FOR ASCENDING DOPAMINERGIC MEDIATION

被引：26

作者：

CLAVIER, RM

GERFEN, CR

机构：

[1] Department of Anatomy, Northwestern University Medical School, Chicago, IL 60611

来源：

NEUROSCIENCE LETTERS | 1979年 / 12卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96059-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intracranial self-stimulation (ICSS) of the prefrontal cortex dorsal to the rhinal sulcus in rats has been abolished by means of injections of 6-hydroxydopamine (6-OHDA) ( 4 μg 2 μl) into the ascending trajectory of the A10 mesocortical dopaminergic fibers ipsilateral to the stimulation electrodes. Similar injections made contralateral to the stimulation electrodes produced a transient attenuation of this self-stimulation. All cases of such lesions were confirmed with the use of Vibratome® histochemical fluorescence examination of each of the dopamine projection areas in the forebrain. © 1979.

引用

页码：183 / 187

页数：5

共 11 条

[1] ROLE OF ASCENDING CATECHOLAMINERGIC PROJECTIONS IN INTRACRANIAL SELF-STIMULATION OF SUBSTANTIA NIGRA [J].