APPARENT INNERVATION OF RAT BASOPHILIC LEUKEMIA (RBL-2H3) CELLS BY SYMPATHETIC NEURONS INVITRO

被引：30

作者：

BLENNERHASSETT, MG

BIENENSTOCK, J

机构：

[1] Department of Pathology, McMaster University Health Sciences Centre, Hamilton, Ont.

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 01期

基金：

英国医学研究理事会;

关键词：

Electron microscopy; Mast cell; Nervous system; Neuroimmunology; Neurotransmitter; Tissue culture;

D O I：

10.1016/0304-3940(90)90165-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Association of mast cells (MCs) and nerves may represent communication between the immune and nervous systems. The morphological features of associations between sympathetic neurons and rat basophilic leukaemia cells (RBL), a model for the mucosal mast cell, were studied in a tissue culture model. Initially, neuronal growth cones contacted single RBL with large areas of membrane apposition. With time, these appeared as distinct zones of contact where intervening distances were ≦50 nm. Large dense-cored granules suggested localization of peptidergic neurotransmitters. Encircling of neurite profiles by RBL resembled intimate nerve-MC relationships in vivo. These modifications may serve to optimize the area of interaction. © 1990.

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页码：50 / 54

页数：5

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