CARCINOGENICITY OF FIBERS AND FILMS - THEORY

被引：25

作者：

ARCHER, VE ^{[1
]}

DIXON, WC ^{[1
]}

机构：

[1] OCCUPAT SAFETY & HLTH ADM,SALT LAKE CITY,UT

来源：

MEDICAL HYPOTHESES | 1979年 / 5卷 / 11期

关键词：

Carcinogenicity; carcinogens; carcinoma; environmental; fibers; films; Foreign bodies; oxygen; phagocytosis;

D O I：

10.1016/0306-9877(79)90008-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A theory based on frustrated phagocytosis is advanced to explain the carcinogenesis of fibers and films. Exocytosis combined with flexion of a foreign body permits the escape of superoxide radicals which, in a manner similar to that postulated for ionizing radiation, induces somatic mutations. The theory is subject to experimental verification, and offers hope for the development of preventive therapy which can be used to prevent some of the fibrosis and cancer resulting from asbestos inhalation. © 1979.

引用

页码：1257 / 1262

页数：6

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