EXERCISE TOLERANCE AFTER ANEMIA CORRECTION WITH RECOMBINANT-HUMAN-ERYTHROPOIETIN IN END-STAGE RENAL-DISEASE

被引：23

作者：

BARALDI, E

MONTINI, G

ZANCONATO, S

ZACCHELLO, G

ZACCHELLO, F

机构：

[1] Department of Paediatrics, University of Padua, Padua, I-35 128

来源：

PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 06期

关键词：

HEMODIALYSIS; ANEMIA; EXERCISE TESTING; RECOMBINANT HUMAN ERYTHROPOIETIN; REHABILITATION;

D O I：

10.1007/BF00858638

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The aim of this study was to evaluate the effect of correction of chronic anaemia on the physical performance and the cardiovascular response to effort in children with end-stage renal disease (ESRD) maintained by haemodialysis. Seven patients (mean age 13.9 years) underwent triangular-type treadmill exercise testing before [haemoglobin (Hb) 6.3+/-0.9 g/dl] and after (Hb 11.2+/-1.2 g/dl) anaemia correction with recombinant human erythropoietin (rHuEPO). After treatment, the work-load reached, the peak oxygen uptake and average ventilatory anaerobic threshold (VAT) values were significantly increased (P < 0.01, P < 0.001, P < 0.05 respectively). VAT values, expressed as a percentage of normal values, increased from 55.7+/-16.6% to 82.4+/-21%. This improvement correlated well with the increase in Hb (r = 0.79). Oxygen pulse also increased significantly, when tested after anaemia correction. In conclusion, these data demonstrate that when the anaemia of children with ESRD is corrected with rHuEPO, there is a clear improvement in aerobic work capacity and effort tolerance.

引用

页码：623 / 626

页数：4

共 19 条

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