STRUCTURE PREDICTIONS OF MEMBRANE-PROTEINS ARE NOT THAT BAD

被引：146

作者：

JAHNIG, F

机构：

[1] Max-Planck-Institut für Biologie, D-7400 Tübingen

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 03期

关键词：

D O I：

10.1016/0968-0004(90)90188-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple generalization of the well-known hydrophobicity analysis is sufficient to predict membrane-spanning amphiphilic α-helices and β-strands. The use of this method is illustrated for bacteriorhodopsin, OmpA protein and the photosynthetic reaction centre. © 1990.

引用

收藏

页码：93 / 95

页数：3

相关论文

共 16 条

[1]

CHOU DY, 1978, ANNU REV BIOCHEM, V47, P251

[2] STRUCTURE OF THE PROTEIN SUBUNITS IN THE PHOTOSYNTHETIC REACTION CENTER OF RHODOPSEUDOMONAS-VIRIDIS AT 3A RESOLUTION [J].

DEISENHOFER, J ;

EPP, O ;

MIKI, K ;

HUBER, R ;

MICHEL, H .

NATURE, 1985, 318 (6047) :618-624

[3] THE HYDROPHOBIC MOMENT DETECTS PERIODICITY IN PROTEIN HYDROPHOBICITY [J].

EISENBERG, D ;

WEISS, RM ;

TERWILLIGER, TC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :140-144

[4] IS HYDROPHOBICITY ANALYSIS SUFFICIENT TO PREDICT TOPOGRAPHY OF MEMBRANE-PROTEINS [J].

FERENCI, T .

TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (03) :96-96

[5] AMPHIPATHIC ANALYSIS AND POSSIBLE FORMATION OF THE ION CHANNEL IN AN ACETYLCHOLINE-RECEPTOR [J].

FINERMOORE, J ;

STROUD, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :155-159

[6] 3-DIMENSIONAL MODEL OF PURPLE MEMBRANE OBTAINED BY ELECTRON-MICROSCOPY [J].

HENDERSON, R ;

UNWIN, PNT .

NATURE, 1975, 257 (5521) :28-32

[7]

JAHNIG F, 1989, PREDICTION PROTEIN S, P707

[8] THE DETECTION AND CLASSIFICATION OF MEMBRANE-SPANNING PROTEINS [J].

KLEIN, P ;

KANEHISA, M ;

DELISI, C .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 815 (03) :468-476

[9] A SIMPLE METHOD FOR DISPLAYING THE HYDROPATHIC CHARACTER OF A PROTEIN [J].

KYTE, J ;

DOOLITTLE, RF .

JOURNAL OF MOLECULAR BIOLOGY, 1982, 157 (01) :105-132

[10] STRUCTURAL PRINCIPLES OF ALPHA-BETA-BARREL PROTEINS - THE PACKING OF THE INTERIOR OF THE SHEET [J].

LESK, AM ;

BRANDEN, CI ;

CHOTHIA, C .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1989, 5 (02) :139-148