ALTERATION OF POTASSIUM-EVOKED 5-HT RELEASE FROM VIRUS-INFECTED RAT CORTICAL SYNAPTOSOMES

被引：30

作者：

BOUZAMONDO, E ^{[1
]}

LADOGANA, A ^{[1
]}

TSIANG, H ^{[1
]}

机构：

[1] INST PASTEUR, UNITE RAGE, 25 RUE DR ROUX, F-75724 PARIS 15, FRANCE

来源：

NEUROREPORT | 1993年 / 4卷 / 05期

关键词：

SEROTONIN (5-HT); K+ EVOKED RELEASE; RABIES VIRUS; RAT CORTICAL SYNAPTOSOMES; BEHAVIORAL DISTURBANCE;

D O I：

10.1097/00001756-199305000-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

POTASSIUM-evoked H-3-serotonin (5-HT) release from rat cerebrocortical synaptosomes was performed after peripheral inoculation with fixed rabies virus CVS (challenge virus strain). At the onset of clinical symptoms, the rats were sacrificed, synaptosomes were prepared from dissected cortices and assayed for K+ evoked 5-HT release. The results show a decrease in evoked 5-HT release from virus-infected synaptosomes. Alterations in serotoninergic transmission in rabies virus infected brain cortex indicate a possible involvement in the triggering of pathogenetic mechanisms relating to the clinicopathological manifestations of the viral disease.

引用

页码：555 / 558

页数：4

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