LEUALACIN, A NOVEL CALCIUM BLOCKER FROM HAPSIDOSPORA-IRREGULARIS .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：17

作者：

HAMANO, K ^{[1
]}

KINOSHITA, M ^{[1
]}

FURUYA, K ^{[1
]}

MIYAMOTO, M ^{[1
]}

TAKAMATSU, Y ^{[1
]}

HEMMI, A ^{[1
]}

TANZAWA, K ^{[1
]}

机构：

[1] SANKYO CO LTD,TSUKUBA RES LABS,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 06期

关键词：

D O I：

10.7164/antibiotics.45.899

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new calcium blocker, designated leualacin, has been isolated from Hapsidospora irregularis. The compound inhibits the binding of H-3-nitrendipine, a well known synthetic calcium blocker, to cardiac Ca channel in a competitive manner, although its structure is completely different from dihydropyridines.

引用

页码：899 / 905

页数：7

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