DEMINERALIZED BONE-MATRIX - ENHANCEMENT OF SPINAL-FUSION

被引：68

作者：

FRENKEL, SR

MOSKOVICH, R

SPIVAK, J

ZHANG, ZH

PREWETT, AB

机构：

[1] Hospital for Joint Diseases Orthopaedic Institute, New York, NY

[2] Osteotech Inc., Shrewsbury, NJ

来源：

SPINE | 1993年 / 18卷 / 12期

关键词：

SPINAL FUSION; DEMINERALIZED BONE; OSTEOCONDUCTION; OSTEOINDUCTION; CANINE MODEL;

D O I：

10.1097/00007632-199309000-00011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A study was conducted to determine the ability of demineralized bone matrix gel to act as an osteoconductive/osteoinductive material to enhance canine spinal fusion. Seven dogs underwent posterior spinal fusion. Four-level fusions were performed with one of four procedures at each level: decortication alone, with gel added, with autograft, or with both gel and autograft. Dogs were killed at 6 weeks and early histologic response was studied. At untreated control sites, little bone formation was evident. Gel-filled sites showed abundant osteoid, with 60% of demineralized particles fused to or surrounded by new bone. Sites filled with autograft had more new bone, but there was more osteoid at gel-treated sites. Autograft augmented with gel showed the most vigorous response, with extensive bridging between demineralized particles, host bone, autograft, and new bone. Significantly less autograft was needed to induce a similar amount of new bone formation when gel was added. Use of the gel as an autograft extender may improve the chance for successful spinal fusion.

引用

页码：1634 / 1639

页数：6

共 18 条

[1]

Bunnell W.P., Anterior spinal fusion: Experimental evaluation of technique, J Pediatr Orthop, 2, pp. 469-477, (1982)

[2]

Cook S.D., Reynolds M.C., Whitecloud T.S., Et al., Evaluation of hydroxylapaptite graft materials in canine cervical spine fusions, Spine, 11, pp. 305-309, (1986)

[3]

Daculsi G., Passuti N., Martin S., Et al., Comparative study of bioactive calcium phosphate ceramics after implantation in spongy bone in dogs: Histologic, ultrastructural, and electron probe microanalysis, Rev Chirurgie Orthop Repar Appar Mot, 75, pp. 65-71, (1989)

[4]

Dawson E.G., Clader T.J., Bassett L.W., A comparison of different methods to diagnose pseudoarthrosis following posterior spinal fusion for scoliosis, J Bone Joint Surg, 67A, pp. 1153-1160, (1985)

[5]

Einhorn T.A., Lane J.M., Burstein A.H., Kopman C.R., Vigorita V.J., The healing of segmental bone defects induced by demineralized bone matrix, J Bone Joint Surg, 66A, pp. 274-279, (1984)

[6]

Glowacki J., Murray J.E., Kaban L.B., Folkman J., Mulliken J.B., Application of the biological principle of induced osteogenesis for craniofacial defects, Lancet Ii, pp. 959-963, (1981)

[7]

Guizzardi S., Di Silvestre M., Scandroglio R., Ruggeri A., Savini R., Implants of heterologous demineralized bone matrix for induction of posterior spinal fusion in rats, Spine, 17, pp. 701-707, (1992)

[8]

Gurr K.R., McAfee P.C., Warden K.E., Shih C.M., Roentgenog- raphic and biomechanical analysis of lumbar fusions: A canine model, J Orthop Res, 7, pp. 838-848, (1989)

[9]

Lovell T.P., Dawson E.G., Nilsson O.S., Urist M.R., Augmentation of spinal fusion with bone morphogenetic protein in dogs, Clin Orthop, 243, pp. 266-274, (1989)

[10]

Martin S., Daculsi G., Passuti N., Le Nihouannen J.C., Lajat Y, Resche F: Some integration within calcium phosphate ceramic by creation of posterior inter-articular lumbar spine fusions in dogs, [French] Neuro-Chirurgie, 35, pp. 209-215, (1989)

← 1 2 →