A FACILE METHOD TO APPEND PEPTIDAL SIDE-CHAINS ONTO STEROIDAL TEMPLATES

被引：2

作者：

HORWELL, DC ^{[1
]}

LENNON, IC ^{[1
]}

ROBERTS, E ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,PARKE DAVIS NEUROSCI RES CTR,CAMBRIDGE CB2 2QB,ENGLAND

来源：

TETRAHEDRON | 1994年 / 50卷 / 14期

关键词：

D O I：

10.1016/S0040-4020(01)86716-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Side-chains corresponding to phenylalanine, tyrosine and tryptophan are introduced onto a steroid template in a highly efficient manner via a condensation of the appropriate lithium acetylide with a steroidal ketone. The subsequent acetylene functionality can be selectively reduced in the presence of a modified benzyl ether and steroid ring unsaturation.

引用

页码：4225 / 4234

页数：10

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