BIOLOGICAL HALF-LIVES OF ZINC AND MANGANESE IN RAT-BRAIN

被引：125

作者：

TAKEDA, A ^{[1
]}

SAWASHITA, J ^{[1
]}

OKADA, S ^{[1
]}

机构：

[1] UNIV SHIZUOKA, SCH PHARMACEUT SCI, DEPT RADIOBIOCHEM, SHIZUOKA 422, JAPAN

来源：

BRAIN RESEARCH | 1995年 / 695卷 / 01期

关键词：

BRAIN; ZINC; MANGANESE; BIOLOGICAL HALF-LIFE; ZINC-CONTAINING NEURON TERMINAL;

D O I：

10.1016/0006-8993(95)00916-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brains of rats injected intravenously with (ZnCl2)-Zn-65 or (MnCl2)-Mn-54 were subjected to high-resolution autoradiography. The distribution of Zn-65 and Mn-54 in each brain region gradually decreased from 6 days to 42 days for Zn-65 and from 15 days to 60 days for Mn-54 after the injection. The biological half-lives of Zn in each region studied were in the range of 16-43 days; the longest was observed in the amygdaloid nuclei. The regions where the long biological half-life was observed were consistent with the ones with the high density of Zn-containing neuron terminals reported previously. The biological half-lives of Mn in each region determined were 51-74 days; the longest were those in the hypothalamic nuclei and thalamus.

引用

页码：53 / 58

页数：6

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