THE CONTRIBUTION OF SPECIFIC IMMUNOGLOBULIN-M ANTIBODIES TO THE DIAGNOSIS OF HELICOBACTER-PYLORI INFECTION IN CHILDREN

被引：9

作者：

BLECKER, U

LANCIERS, S

HAUSER, B

DEPONT, SMHB

VANDENPLAS, Y

机构：

[1] Division of Paediatric Gastroenterology, Academic Children’s Hospital, Free University of Brussels

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 1995年 / 7卷 / 10期

关键词：

HELICOBACTER PYLORI; SEROLOGY; DIAGNOSIS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; ENZYME-LINKED IMMUNOSORBENT ASSAY;

D O I：

10.1097/00042737-199510000-00013

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objective: To evaluate the diagnostic value of specific immunoglobulins G and M in the detection of Helicobacter pylori infection. Methods: Sera from 68 H. pylori-infected children and 35 H. pylori-negative children (aged 1-15 years) were examined using recent-generation serum enzyme-linked immunosorbent assay (ELISA) tests (Malakit Helicobacter pylori series; Biolab, Limal, Belgium). Results: All of the investigated children had positive values for immunoglobulin G antibodies. However, anti-H. pylori-specific immunoglobulin M could be detected only in 19 (27.9%) of the 68 children. When compared with the C-13-urea breath test, these findings represent sensitivity, specificity and positive and negative predictive values of 27.9, 100, 100 and 41.7%, respectively, for the serum ELISA test for the detection of H. pylori-specific immunoglobulin M compared with 100.0, 97.2, 98.5 and 100.0%, respectively, for the Malakit for the the detection of specific immunoglobulin G antibodies. Conclusion: Although H. pylori-specific immunoglobulin G has been established as a reliable indicator of active H. pylori infection, using the Malakit for the detection of H. pylori-specific immunoglobulin M does not seem to be of major value in the diagnosis of H. pylori infection in children.

引用

页码：979 / 983

页数：5

共 28 条

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