NEW PLAYERS IN THE 5-HT RECEPTOR FIELD - GENES AND KNOCKOUTS

被引：117

作者：

LUCAS, JJ

HEN, R

机构：

[1] Center for Neurobiology and Behavior, Columbia University, New York

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1995年 / 16卷 / 07期

关键词：

D O I：

10.1016/S0165-6147(00)89034-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, cloning has revealed the existence of no less than 14 mammalian 5-HT receptors, as well as evidence that isoforms of the 5-HT4 and 5-HT7 receptors are generated by alternative splicing. In addition, molecular biology techniques have provided new tools with which to study the function of 5-HT receptors. For example, new technologies are emerging that will allow the generation of either inducible or tissue-specific knockouts (or both). In this review Jose Lucas and Rene Hen focus on the characteristics of the most recently cloned receptors and the contribution of molecular biology to the understanding of 5-HT receptor function.

引用

页码：246 / 252

页数：7

共 57 条

[1] BARD JA, 1993, J BIOL CHEM, V268, P23422
[2] THE 5-HT4 RECEPTOR - A PLACE IN THE SUN
BOCKAERT, J
FOZARD, JR
DUMUIS, A
CLARKE, DE
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (04) : 141 - 145
[3] BROWN AM, 1993, BRIT J PHARMACOL, V110, pP10
[4] CONNER DA, 1990, MOL PHARMACOL, V37, P742
[5] 5-CARBOXAMIDOTRYPTAMINE IS A SELECTIVE AGONIST AT 5-HYDROXYTRYPTAMINE RECEPTORS MEDIATING VASODILATATION AND TACHYCARDIA IN ANESTHETIZED CATS
CONNOR, HE
FENIUK, W
HUMPHREY, PPA
PERREN, MJ
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1986, 87 (02) : 417 - 426
[6] IDENTIFICATION AND CHARACTERIZATION OF SEROTONIN 5-HT4, RECEPTOR-BINDING SITES IN HUMAN BRAIN - COMPARISON WITH OTHER MAMMALIAN-SPECIES
DOMENECH, T
BELETA, J
FERNANDEZ, AG
GRISTWOOD, RW
SANCHEZ, FC
TOLOSA, E
PALACIOS, JM
[J]. MOLECULAR BRAIN RESEARCH, 1994, 21 (1-2): : 176 - 180
[7] 2 MEMBERS OF A DISTINCT SUBFAMILY OF 5-HYDROXYTRYPTAMINE RECEPTORS DIFFERENTIALLY EXPRESSED IN RAT-BRAIN
ERLANDER, MG
LOVENBERG, TW
BARON, BM
DELECEA, L
DANIELSON, PE
RACKE, M
SLONE, AL
SIEGEL, BW
FOYE, PE
CANNON, K
BURNS, JE
SUTCLIFFE, JG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) : 3452 - 3456
[8] 5-HYDROXYTRYPTAMINE STIMULATES 2 DISTINCT ADENYLATE-CYCLASE ACTIVITIES IN RAT-BRAIN - HIGH-AFFINITY ACTIVATION IS RELATED TO A 5-HT1 SUBTYPE DIFFERENT FROM 5-HT1A, 5-HT1B, AND 5-HT1C
FAYOLLE, C
FILLION, MP
BARONE, P
OUDAR, P
ROUSSELLE, JC
FILLION, G
[J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1988, 2 (03) : 195 - 214
[9] THE 5-HT(4)- RECEPTOR
FORD, APDW
CLARKE, DE
[J]. MEDICINAL RESEARCH REVIEWS, 1993, 13 (06) : 633 - 662
[10] TEMPORAL CONTROL OF GENE-EXPRESSION IN TRANSGENIC MICE BY A TETRACYCLINE-RESPONSIVE PROMOTER
FURTH, PA
STONGE, L
BOGER, H
GRUSS, P
GOSSEN, M
KISTNER, A
BUJARD, H
HENNIGHAUSEN, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (20) : 9302 - 9306

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