FURTHER-STUDIES ON RELATIONSHIP BETWEEN INSULIN RELEASE AND LANTHANUM-NONDISPLACEABLE CA-45(2+) UPTAKE BY PANCREATIC-ISLETS - EFFECTS OF FRUCTOSE AND STARVATION

被引：24

作者：

HELLMAN, B ^{[1
]}

IDAHL, LA ^{[1
]}

LENZEN, S ^{[1
]}

SEHLIN, J ^{[1
]}

TALJEDAL, IB ^{[1
]}

机构：

[1] UNIV UMEA,DEPT HISTOL,S-90187 UMEA 6,SWEDEN

来源：

ENDOCRINOLOGY | 1978年 / 102卷 / 06期

关键词：

D O I：

10.1210/endo-102-6-1856

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Relationships between the release of insulin and the incorporation of 4aCa2+ into a lanthanumnondisplaceable (intracellular) pool were studied in islets microdissected from the pancreatic glands of noninbred 0b/0b mice. In comparison with D-glucose, Dfructose was slowly oxidized and had only marginal effects on insulin release. However, fructose was as effective as glucose in stimulating the lanthanum-nondisplaceable 4SCa2+ uptake. The 45Ca2+ uptake was dosedependent on the concentration of fructose in the range 0-20 mM; the same dose-dependence was obtained with glucose. Fasting the mice for 3 days caused a total block of the insulin secretory response to 20 mM glucose, but it produced an enhancement of the glucose-induced 45Ca2+ uptake. Both the inhibition of insulin release and the enhancement of 45Ca2+ uptake were counteracted by pretreating the isolated islets with 20-40 mM D-glucose; pretreatment with L-glucose or fructose could not counteract the effects of fasting. Although some functional relationship may exist between the lanthanum-nondisplaceable uptake of 4aCa2+ and the insulin secretory apparatus, it is concluded that the uptake of Ca2+ is not simply the result of stimulated insulin release. © 1978 by The Endocrine Society.

引用

页码：1856 / 1863

页数：8

共 20 条

[1]

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[2]

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[3]

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[4]

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