ENHANCED RESPONSIVENESS TO INTRA-VENTRICULAR INFUSION OF AMPHETAMINE FOLLOWING ITS REPEATED SYSTEMIC ADMINISTRATION

Previous studies have demonstrated that long-term administration of d-amphetamine produces a progressive augmentation of behavior. In the present experiment, rats receiving repeated systemic injections responded to an intraventricular infusion of d-amphetamine with an augmented increase in locomotor activity. These results indicate that central mechanisms, rather than peripheral dispositional factors, subserve the enhanced behavioral response to repeated amphetamine administration. © 1979 Springer-Verlag.