HYDROXYLATION AND SULFATION OF BILE-ACIDS IN RAT HEPATOMA CULTURES UNDER THE INFLUENCE OF A GLUCOCORTICOID

被引：22

作者：

LAMBIOTTE, M ^{[1
]}

SJOVALL, J ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT CHEM,S-10401 STOCKHOLM 60,SWEDEN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)90229-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

When treated with a glucocorticoid, monolayer cultures of a differentiated rat hepatoma convert added chenodeoxycholic and deoxycholic acids into compounds not formed by untreated cultures. The main metabolites have been identified. Chenodeoxycholic acid was 6β-hydroxylated to yield α-muricholic acid, whereas deoxycholic acid was converted mainly into its 3-sulfate. In addition, deoxycholic acid was hydroxylated in 6β-, 7α- and 1ξ-positions. Thus, glucocorticoids appear to induce one 6β-hydroxylase in particular and a sulfotransferase having a notable substrate selectivity. © 1979.

引用

页码：1089 / 1095

页数：7

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