REGIONAL VARIATION IN PRIMARY SKIN IRRITATION AND CORROSIVITY POTENTIALS IN RABBITS

被引:4
作者
VINEGAR, MB
机构
[1] Hill Top Research, Inc., Miamiville
关键词
D O I
10.1016/0041-008X(79)90277-1
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Both the backs and abdomens of rabbits were tested simultaneously for primary skin irritation and corrosivity potentials of 33 samples. A modified Draize procedure was used. The Primary Irritation Indices of the abdomens were significantly higher than those of the backs. This difference was not due to either erythema or edema scores alone. The variability between individual scores was significantly greater for the abdomen than for the back for a given sample. The site of application is a potential source of variation between laboratories in primary irritation test results. © 1979.
引用
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页码:63 / 69
页数:7
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