VITAMIN-D - A MODULATOR OF CELL-PROLIFERATION AND DIFFERENTIATION

被引：98

作者：

POLS, HAP ^{[1
]}

BIRKENHAGER, JC ^{[1
]}

FOEKENS, JA ^{[1
]}

VANLEEUWEN, JPTM ^{[1
]}

机构：

[1] DR DANIEL DEN HOED CANC CTR,ROTTERDAM,NETHERLANDS

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1990年 / 37卷 / 06期

关键词：

D O I：

10.1016/0960-0760(90)90435-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1,25-Dihydroxyvitamin D3, [1,25(OH)2D3], the biologically most active metabolite of vitamin D3, is involved in the regulation of calcium homeostasis and bone metabolism. Recently, receptors for 1,25(OH)2D3 have also been shown in cells and tissues not directly related to calcium homeostasis. Experimental data obtained with leukaemic and cancer cell lines, both in vitro and in vivo, showed the effects of 1,25(OH)2D3 on cell differentiation and proliferation. However, high doses of the sterol have to be used to observe these effects. Additional studies are needed to establish whether 1,25(OH)2D3 or suitable analogues have a therapeutic potential in malignant diseases without unacceptable toxicity like the development of hypercalcemia.

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页码：873 / 876

页数：4

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