EPSTEIN-BARR-VIRUS RECEPTORS BUT NOT VIRAL-DNA ARE PRESENT IN NORMAL AND MALIGNANT ORAL EPITHELIUM

被引:41
作者
TALACKO, AA
TEO, CG
GRIFFIN, BE
JOHNSON, NW
机构
[1] ROYAL COLL SURG ENGLAND,HUNTERIAN INST,DEPT DENT SCI,35-43 LINCOLNS INN FIELDS,LONDON WC2A 3PN,ENGLAND
[2] ROYAL POSTGRAD MED SCH,DEPT VIROL,LONDON W12 0HS,ENGLAND
关键词
D O I
10.1111/j.1600-0714.1991.tb00882.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The presence and distribution of Epstein-Barr Virus receptors (EBVR's) on a range of normal (n = 18), dysplastic (n = 10) and malignant (n = 20) oral mucosa were studied by immunocytochemical methods using the monoclonal antibodies (MAb's) HB5 and B2. EBVR's were demonstrated as membrane staining of the spinous layers of normal non- and parakeratinized epithelium, indicating that EBVR's are differentiation-linked. This distribution was retained in dysplastic epithelium. Tissue from oral squamous cell carcinomas (SCC's) showed variable reactivity of only a few cells scattered randomly within the samples. Furthermore, a sensitive in situ hybridization (ISH) technique was used to determine if Epstein-Barr virus (EBV) was present in normal (n = 15) and oral squamous cell carcinoma tissues (n = 20). No EBV DNA was demonstrated within either normal or malignant epithelium, suggesting that the virus does not persist in normal oral stratified squamous epithelium nor is there any evidence for a role in oral carcinogenesis.
引用
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页码:20 / 25
页数:6
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