PLASMA-EXCHANGE AND INTRAVENOUS IMMUNOGLOBULIN TREATMENT OF THE MOTHER TO DIMINISH FETAL RHESUS HEMOLYTIC-DISEASE

被引：14

作者：

BERLIN, G

SELBING, A

GOTTVALL, T

机构：

[1] Blood Center, University Hospital

[2] Department of Obstetrics and Gynecology, University Hospital

来源：

TRANSFUSION SCIENCE | 1990年 / 11卷 / 01期

关键词：

D O I：

10.1016/0955-3886(90)90014-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Three pregnant women with a previous history of and laboratory findings consistent with severe rhesus immunization were treated with high-dose intravenous immunoglobulin (IVIG) after a mean reduction of the antibody concentration of 64% by plasma exchange. Two of the cases were successful as judged by the clinical condition of the newborns, the slow increase in serum anti-D concentrations, and the decrease in amniotic fluid bilirubin levels after the combined treatment. The effect was less pronounced in the third case treated with a different preparation of IVIG. The maternal antibody production rate seems to be decreased by IVIG treatment and the placental transfer of IgG antibodies may also be affected. However, as anti-D antibodies were found at a high concentration in the blood of the newborns, we suggest that a major effect of the treatment is decreased fetal hemolysis, which may be caused by blockade of the fetal reticuloendothelial system. © 1990.

引用

页码：85 / 90

页数：6

共 21 条

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