The multidrug resistance P-glycoprotein

被引：40

作者：

Higgins, Christopher F. ^{[1
]}

机构：

[1] Univ Oxford, ICRF, Oxford OX3 9DU, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1016/0955-0674(93)90140-L

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

P-glycoprotein plays an important role in the resistance of cancers to chemotherapy. Thus, an understanding of the mechanism by which it functions, and its 'normal' physiological role, is of clinical relevance as well as intrinsic interest. Considerable progress towards this goal has been made in the last year or so. In addition, the finding that P-glycoprotein is associated with both a channel and a transporter activity has, potentially, far-reaching implications for an understanding of the nature of channels and transporters.

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收藏

页码：684 / 687

页数：4

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