PORTAL TRANSPORT OF LONG ACYL-CHAIN LIPIDS - EFFECT OF PHOSPHATIDYLCHOLINE AND LOW INFUSION RATES

被引:25
作者
MANSBACH, CM [1 ]
DOWELL, RF [1 ]
机构
[1] VET ADM MED CTR, MEMPHIS, TN 38104 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 264卷 / 06期
关键词
PORTAL VEIN; LIPID ABSORPTION; INTESTINE;
D O I
10.1152/ajpgi.1993.264.6.G1082
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The transport of absorbed long acyl chain lipids in the portal vein of rats has been shown to be 39% when the duodenal input rate is 135 mumol/h glyceryl trioleate (TO) [C. M. Mansbach II, R. F. Dowell, and D. Pritchett, Am. J. Physiol. 255 (Gastrointest. Liver Physiol. 18): G530-G539, 1991]. These calculations were based on a new experimental model in which portal flux is calculated from the knowledge of portal flow and the concentration of the lipids in excess in the portal vein vs. the carotid artery. To test this model, rats were infused for 6 h with a low rate of [H-3]TO (27 mumol/h) with or without phosphatidylcholine (9 mumol/h) or with [H-3]TO (135 mumol/h) plus phosphatidylcholine (9 mumol/h). In all three cases, portal flux was expected to be less. Portal transport was 16.5% of the input rate in the low-dose group, 1.4% in the high-dose group given phosphatidylcholine, and 0.5% in the low-dose plus phosphatidylcholine group. There was no net transport of fatty acid in the portal vein in any of the three cases. These data show that portal lipid transport is dependent on the lipid load and that it is greatly reduced at high loads by including phosphatidylcholine in the lipid infusion.
引用
收藏
页码:G1082 / G1089
页数:8
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