REGULATION OF BDNF PROMOTERS IN THE RAT HIPPOCAMPUS

被引：33

作者：

TIMMUSK, T ^{[1
]}

METSIS, M ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS,MOLEC NEUROBIOL LAB,S-17177 STOCKHOLM,SWEDEN

来源：

NEUROCHEMISTRY INTERNATIONAL | 1994年 / 25卷 / 01期

关键词：

D O I：

10.1016/0197-0186(94)90046-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brain-derived neurotrophic factor belongs to the neurotrophin family of trophic factors. Recently we have described four promoters in the BDNF gene. We have analyzed the hippocampal expression pattern of BDNF mRNA's containing different 5' exons during postnatal development. This analysis has revealed distinct regulation of promoters I and II compared to promoters III and IV, which suggests the presence of common regulatory elements for these clusters of promoters. Induction of different BDNF promoters after treatment with kainic acid combined with glutamate antgonists MK801 and NBQX discloses the differential participation of different glutamate receptor subtypes in regulation of the BDNF gene in the hippocampus

引用

页码：11 / 15

页数：5

共 33 条

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