AGMATINE - A NOVEL ENDOGENOUS VASODILATOR SUBSTANCE

被引：31

作者：

GAO, YQ

GUMUSEL, B

KOVES, G

PRASAD, A

HAO, QZ

HYMAN, A

LIPPTON, H

机构：

[1] TULANE UNIV,SCH MED,DEPT SURG,NEW ORLEANS,LA 70112

[2] LOUISIANA STATE UNIV,SCH MED,DEPT PHARMACOL,NEW ORLEANS,LA 70112

[3] TULANE UNIV,SCH MED,DEPT PHARMACOL & INTERNAL MED,NEW ORLEANS,LA 70112

来源：

LIFE SCIENCES | 1995年 / 57卷 / 08期

关键词：

CLONIDINE-DISPLACING SUBSTANCE; AGMATINE; VASODILATION;

D O I：

10.1016/0024-3205(95)02011-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.

引用

页码：PL83 / PL86

页数：4