RENAL CLEARANCES OF LABELLED INULIN (INULIN-CARBOXYL-14C, INULIN-METHOXY-3H) AND A POLYETHYLENE GLYCOL (PEG 1000) IN RAT

被引：28

作者：

BERGLUND, F

ENGBERG, A

PERSSON, E

ULFENDAHL, H

机构：

[1] Department of Food Hygiene, National Institute of Public Health, Stockholm

[2] Department of Surgery, University Hospital, Uppsala

[3] Department of Physiology, University of Uppsala

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1969年 / 76卷 / 04期

关键词：

D O I：

10.1111/j.1748-1716.1969.tb04492.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The simultaneous renal clearances of 14C‐inulin, 3H‐inulin and PEG 1000 were measured in 10 unanesthetized male Sprague‐Dawley rats by a constant infusion technique. Both the 3H‐inulin/PEG 1000 and the 3H‐inulin/14G‐inuiin clearance ratios were significantly below unity. There was a negative correlation between 3H‐inulin/PEG 1000 or 14C‐inuIin/PEG 1000 clearance ratios and the clearance of PEG 1000, indicating more efficient “sieving” at increased filtration rates. Inulin (unlabelled, as well as labelled derivatives) is considered unsuitable for the accurate measurement of glomerular filtration rate in the rat. © 1969 Scandinavian Physiological Society

引用

页码：458 / +

页数：1

共 16 条

[1] AVERILL CM, 1966, CLIN SCI, V31, P353
[2] RENAL EXCRETION AND VOLUME OF DISTRIBUTION OF POLYETHYLENE GLYCOL (PEG) IN RAT AND DOG
BERGLUND, F
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1968, 73 (1-2): : A20 - &
[3] RENAL CLEARANCES OF INULIN POLYFRUCTOSAN-S AND A POLYETHYLENE GLYCOL (PEG 1000) IN RAT
BERGLUND, F
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1965, 64 (03): : 238 - &
[4] REABSORPTION OF INORGANIC SULFATE BY RENAL TUBULES OF RAT
BERGLUND, F
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1964, 62 (04): : 336 - &
[5] CHEN PS, 1964, P SOC EXP BIOL MED, V116, P40
[6] CHEN PS, 1963, P SOC EXP BIOL MED, V113, P584
[7] DANIELSON BG, 1966, ACTA SOC MED UPS, P173
[8] LIQUID SCINTILLATION COUNTING OF 14C AND 3H SAMPLES USING GLASS-FIBRE OR FILTER-PAPER DISCS
DAVIES, JW
COCKING, EC
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1966, 115 (02) : 511 - &
[9] A TECHNIQUE FOR REPEATED RENAL CLEARANCE MEASUREMENTS IN UNDISTURBED RATS
ENGBERG, A
[J]. ACTA PHYSIOLOGICA SCANDINAVICA, 1969, 75 (1-2): : 170 - &
[10] FALBRIAR.A, 1967, HELV PHYSIOL PHARM A, V25, P123

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