INHOMOGENEOUS DISTRIBUTION OF FILIPIN-STEROL COMPLEXES IN THE CILIARY MEMBRANE OF RAT TRACHEAL EPITHELIUM

被引：43

作者：

MONTESANO, R

机构：

[1] Institute of Histology and Embryology, School of Medicine, University of Geneva

来源：

AMERICAN JOURNAL OF ANATOMY | 1979年 / 156卷 / 01期

关键词：

D O I：

10.1002/aja.1001560115

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Pieces of rat trachea fixed in a glutaraldehyde solution containing 300 m̈M filipin, a sterol‐specific polyene antibiotic (Elias et al., '78), were freeze‐fractured in order to study the distribution of cholesterol within the ciliary membrane. Filipin‐sterol complexes, recognizable as 25–30‐nm protrusions on fracture faces, appeared densely and uniformly distributed over most of the ciliary membrane, but were absent from the region of the ciliary necklace. It is possible, therefore, that the ciliary necklace represents a cholesterol‐poor area of membrane. Copyright © 1979 Wiley‐Liss, Inc.

引用

页码：139 / 145

页数：7

共 15 条

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