THE EFFECT OF ADSORBED COATS OF POLOXAMER-237 AND POLOXAMER-338 ON THE INVITRO AGGREGATION AND INVIVO DISTRIBUTION OF POLYSTYRENE LATEX (PSL) PARTICLES

被引：16

作者：

OMULLANE, JE

PETRAK, K

HUTCHINSON, LEF

TOMLINSON, E

机构：

[1] Advanced Drug Delivery Research Unit, Ciba-Geigy Pharmaceuticals, Horsham, RH12 4AB, Wimblehurst Road

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 63卷 / 02期

关键词：

Colloid; Drug delivery; Fibrinogen; Phagocytosis; Poloxamers; Targeting;

D O I：

10.1016/0378-5173(90)90169-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Poloxamer-coated PSL has been used to examine the effect of adsorbed hydrophilic layers on the biological dispersion of intravenously injected hydrophobic particles. The localisation of uncoated particles in the lungs and liver is caused by protein adsorption and aggregation, which has been verified by in vitro observations. Increasing the thickness - and presumably the packing - of the adsorbed polymer layer results in the redistribution of particles from the lungs to other tissues. © 1990.

引用

页码：177 / 180

页数：4

共 12 条

[1]

BRADFIELD JWB, 1984, MICROSPHERES DRUG TH, P25

[2] PARTICLE-SIZE AND SIZE DISTRIBUTION OF POLY(BUTYL 2-CYANOACRYLATE) NANOPARTICLES .2. INFLUENCE OF STABILIZERS [J].