INVITRO BIOSYNTHESIS OF 18-HYDROXY-11-DEOXYCORTICOSTERONE FROM DEOXYCORTICOSTERONE BY HUMAN ADRENAL-GLANDS REMOVED FROM PATIENTS WITH HYPERCORTICISM

被引：2

作者：

TOUITOU, Y ^{[1
]}

BOGDAN, A ^{[1
]}

LUTON, JP ^{[1
]}

机构：

[1] HOP COCHIN,DEPT ENDOCRINOL,F-75674 PARIS 14,FRANCE

来源：

CLINICAL ENDOCRINOLOGY | 1979年 / 11卷 / 01期

关键词：

D O I：

10.1111/j.1365-2265.1979.tb03044.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The biosynthesis of 18‐hydroxy‐ll‐deoxycorticosterone (18‐OH‐DOC) was studied by in vitro incubations of human adrenals resected from patients with Cushing's syndrome, using deoxycorticosterone as precursor. 18‐OH‐DOC synthesis was similar in adrenals from normal subjects and in those derived from patients with different types of Cushing's syndrome (hyperplasia, adenoma, carcinoma). The in vitro addition of o,p'‐DDD (5 X 10‐3 M) to an adrenocortical carcinoma incubation did not alter 18‐OH‐DOC biosynthesis. By contrast, treatment of the patient with o,p'‐DDD prior to adrenalectomy resulted in a low production of 18‐OH‐DOC in vitro but only when cortisol synthesis was drastically decreased. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：39 / 45

页数：7

共 16 条

[1] BIOSYNTHESIS IN VITRO OF 18-HYDROXY-11-DEOXYCORTICOSTERONE BY INTERRENAL TISSUE OF RAINBOW TROUT [J].