LONG-TERM EFFECTS OF NEUROPEPTIDE-Y ON THE RAT ADRENAL-CORTEX

被引：24

作者：

LESNIEWSKA, B

NOWAK, M

MISKOWIAK, B

NUSSDORFER, GG

MALENDOWICZ, LK

机构：

[1] UNIV PADUA,DEPT ANAT,VIA GABELLI 65,I-35121 PADUA,ITALY

[2] MED ACAD POZNAN,DEPT HISTOL & EMBRYOL,PL-60780 POZNAN,POLAND

来源：

NEUROPEPTIDES | 1990年 / 16卷 / 01期

关键词：

D O I：

10.1016/0143-4179(90)90023-R

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adult female rats, intact or dexamethasone suppressed, were i.p. injected twice a day for 4 consecutive days with 0.5 ug neuropeptide-Y (NPY). In intact rats, NPY lowered serum ACTH and aldosterone levels, and had no effects either on serum and adrenal corticosterone or the morphology of the adrenal cortex. In dexamethasone-treated rats, NPY again decreased serum aldosterone concentration. Moreover, it caused a small but significant drop both in the volume of zona fasciculata cells and the adrenal content of corticosterone. These findings seem to suggest an inhibitory effect of NPY on the function of rat zona glomerulosa and perhaps zona fasciculata. © 1990.

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页码：9 / 13

页数：5

相关论文

共 25 条

[1] NEUROPEPTIDE-Y (NPY) IN THE ADRENAL-GLAND [J].

ALLEN, JM ;

ADRIAN, TE ;

POLAK, JM ;

BLOOM, SR .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1983, 9 (2-3) :559-563

[2] OPPOSITE EFFECTS OF NEUROPEPTIDE-Y (NPY) AND POLYPEPTIDE-YY (PYY) ON PLASMA-IMMUNOREACTIVE ATRIAL-NATRIURETIC-FACTOR (IR-ANF) IN RATS [J].

BARANOWSKA, B ;

GUTKOWSKA, J ;

LEMIRE, A ;

CANTIN, M ;

GENEST, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 145 (02) :680-685

[3] NEUROPEPTIDE-Y IS LOCALIZED TOGETHER WITH ENKEPHALINS IN ADRENERGIC GRANULES OF BOVINE ADRENAL-MEDULLA [J].

BASTIAENSEN, E ;

DEBLOCK, J ;

DEPOTTER, WP .

NEUROSCIENCE, 1988, 25 (02) :679-686

[4] NEUROPEPTIDE-Y INHIBITS RENIN RELEASE BY A PERTUSSIS TOXIN-SENSITIVE MECHANISM [J].

HACKENTHAL, E ;

AKTORIES, K ;

JAKOBS, KH ;

LANG, RE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (03) :F543-F550

[5]

HIGUCHI H, 1988, J PHARMACOL EXP THER, V244, P468

[6] AGE-RELATED BIDIRECTIONAL CHANGES IN NEUROPEPTIDE-Y PEPTIDES IN RAT ADRENAL-GLANDS, BRAIN, AND BLOOD [J].

HIGUCHI, H ;

YANG, HYT ;

COSTA, E .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1879-1886

[7] EFFECT OF NEUROPEPTIDE-Y ON THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS IN THE DOG [J].

INOUE, T ;

INUI, A ;

OKITA, M ;

SAKATANI, N ;

OYA, M ;

MORIOKA, H ;

MIZUNO, N ;

OIMOMI, M ;

BABA, S .

LIFE SCIENCES, 1989, 44 (15) :1043-1051

[8] IMMUNOHISTOCHEMICAL ANALYSIS OF THE LOCALIZATION OF NEUROPEPTIDES IN THE ADRENAL-GLAND [J].

KONDO, H .

ARCHIVUM HISTOLOGICUM JAPONICUM, 1985, 48 (05) :453-481

[9]

LUNDBERG JM, 1986, ACTA PHYSL SCANDINAV, V126, P232

[10] NEUROPEPTIDE-Y IN BOVINE ADRENAL-GLANDS - DISTRIBUTION AND CHARACTERIZATION [J].

MAJANE, EA ;

ALHO, H ;

KATAOKA, Y ;

LEE, CH ;

YANG, HYT .

ENDOCRINOLOGY, 1985, 117 (03) :1162-1168