CHARACTERIZATION OF THE STIMULATORY EFFECT OF GALANIN ON GROWTH-HORMONE RELEASE FROM THE RAT ANTERIOR-PITUITARY

被引：26

作者：

SATO, M ^{[1
]}

TAKAHARA, J ^{[1
]}

NIIMI, M ^{[1
]}

TAGAWA, R ^{[1
]}

IRINO, S ^{[1
]}

机构：

[1] KAGAWA MED SCH,CENT LABS,KAGAWA 17501,JAPAN

来源：

LIFE SCIENCES | 1991年 / 48卷 / 17期

关键词：

D O I：

10.1016/0024-3205(91)90124-T

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study was undertaken to investigate the direct actions of rat galanin (R-GAL) on growth hormone (GH) release from the rat anterior pituitary in vitro. R-GAL modestly but significantly stimulated GH release without an increase in intra- and extracellular cyclic AMP levels in monolayer cultures of rat anterior pituitary cells. This stimulatory effect of R-GAL was dose-dependent but not additive with that of GH-releasing factor (GRF). R-GAL-stimulated GH release was less sensitive to the inhibitory effect of somatostatin than was GRF-stimulated GH release. In perifusions of rat anterior pituitary fragments, R-GAL induced a gradual and sustained increase of GH release. Incremental GH release derived in part from preformed stored GH. These data confirm that R-GAL acts at the pituitary level to stimulate GH release by a mechanism distinct from that of GRF.

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页码：1639 / 1644

页数：6

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