A NEW APPROACH TO THE MANAGEMENT OF PATIENTS AT RISK OF OVARIAN HYPERSTIMULATION IN AN INVITRO FERTILIZATION PROGRAM

被引：36

作者：

IMOEDEMHE, DAG

CHAN, RCW

SIGUE, AB

PACPACO, ELA

OLAZO, AB

机构：

[1] Human Reproductive Biology Unit, Soliman Fakeeh Hospital, Jeddah 21461

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 08期

关键词：

IVF-ET; OVARIAN HYPERSTIMULATION SYNDROME; GNRHA;

D O I：

10.1093/oxfordjournals.humrep.a137489

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

In this study, we report an alternative method of management of patients at a potential risk of ovarian hyperstimulation syndrome (OHSS) in an in-vitro fertilization (IVF) programme, by the use of gonadotrophin releasing hormone analogue (GnRHa). Thirty eight women considered at risk of this syndrome, having serum oestradiol > 4000 pg/ml following ovarian stimulation, received a GnRHa nasal spray for induction of the preovulatory endogenous luteinizing hormone surge for follicular maturation prior to oocyte recovery. Oocyte recovery (mean oocytes per cycle 18.60 +/- 4.79; range 15 - 35) and IVF were successfully completed in 27 cycles. Twenty six women had embryos replaced and 11 pregnancies occurred (28.9% per operation, 42.3% per replacement cycle). None of the patients developed OHSS. Where there is a risk of OHSS, the use of GnRHa to induce the preovulatory surge of endogenous luteinizing hormone for final follicular maturation provides a successful and more economical alternative to cancellation of cycles.

引用

页码：1088 / 1091

页数：4

共 13 条

[1]

Fivnat-France P., Giacomini-hyperstimulation, Etude Multi-Centrique journées Periconceptologie, (1988)

[2]

Fleming R., Courts J.R.T., Induction of multiple follicular growth in normally menstruating women with endogenous gonadotrophin suppression, Fertil. Steril, 45, pp. 226-230, (1986)

[3]

Friedman C.I., Schmidt G.E., Chang F.E., Kim M.H., Severe hyperstimulation following follicular aspiration, Am. J. Obstet. Gynecol, 15, pp. 436-437, (1984)

[4]

Howies C.M., Macnamee M.C., Edwards R.G., Short-term use of an LHRH agonist to treat poor responders entering an in-vitro fertilization programme, Hum. Reprod, 2, pp. 655-656, (1987)

[5]

Imoedemhe D.A.G., Mahgoub O.A., Wafik A.H., Chan R.C.W., Sigue A.B., Reyes V.V., The in vitro fertilisation programme at the Soliman Fakeeh Hospital Jeddah, Saudi Arabia, J. in Vitro Fertil. Embryo Transfer, 51, pp. 52-53, (1988)

[6]

Imoedemhe D., Chan R., Sigue A., Pacpaco E., Olazo A., Induction of endogenous luteinising hormone surge with LHRH analogue following ovarian stimulation for in vitro fertilisation treatment, Congress Book of Abstracts. Silver Jubilee Congress of Obstetrics and Gynaecology, (1989)

[7]

Imoedemhe D., Chan R., Sigue A., Pacpaco E., Olazo A., Induction of preovulatory LH surge with LHRH analogue in an in vitro fertilisation programme, VII World Congress on Human Reproduction, (1990)

[8]

Imoedemhe D.A.G., Sigue A.B., Pacpaco E.L.A., Olazo A.B., Stimulation of endogenous surge of luteinising hormone with gonadotrophin-releasing hormone analogue after ovarian stimulation for in vitro fertilisation, Fertil. Steril, 55, pp. 328-332, (1991)

[9]

Lunenfeld B., Bloom S., Blanksten J., Résultats De L'induction De L'ovulation Par Les ménotrophines Chorioniques (HMG-HCG), pp. 95-104, (1986)

[10]

Shaw R.W., Ndukwe G., Imoedemhe D.A.G., Barnard A.G., Burford G., Twin pregnancy after pituitary desensitisation with LHRH-agonist and 'pure' FSH, Lancet, 2, pp. 506-507, (1985)

← 1 2 →