DETECTION OF CANINE HOMOLOGS OF HUMAN MYC, BCL2, IGH, AND TCRB GENES BY SOUTHERN BLOT ANALYSIS

被引：11

作者：

CHAGANTI, SR ^{[1
]}

MITRA, J ^{[1
]}

LOBUE, J ^{[1
]}

机构：

[1] NYU,DEPT BIOL,NEW YORK,NY 10003

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 62卷 / 01期

关键词：

D O I：

10.1016/0165-4608(92)90029-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Subsets of non-Hodgkin's lymphoma in humans have been shown to involve activation of protooncogenes such as MYC and BCL2 resulting from chromosome translocation involving the IGH and TCR genes. Malignant lymphomas in the canine present histologic and clinical subsets similar to those in humans. To study the genetic nature of these lymphomas, we undertook this study to determine, by Southern blotting analysis, the extent of homology between the human and canine genes MYC, BCL2, IGH, and TCRB using human gene probes. Our results, presented here, show that the organization of these genes in the two species is very similar.

引用

页码：9 / 14

页数：6

共 20 条

[1]

[Anonymous], 1982, CANCER, V49, P2112

[2] THE STRUCTURE AND EVOLUTION OF THE HUMAN BETA-GLOBIN GENE FAMILY [J].