A POSITION EFFECT IN THE CONTROL OF TRANSCRIPTION AT YEAST MATING TYPE LOCI

被引：196

作者：

NASMYTH, KA ^{[1
]}

TATCHELL, K ^{[1
]}

HALL, BD ^{[1
]}

ASTELL, C ^{[1
]}

SMITH, M ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA, FAC MED, DEPT BIOCHEM, VANCOUVER V6T 1W5, BC, CANADA

来源：

NATURE | 1981年 / 289卷 / 5795期

关键词：

D O I：

10.1038/289244a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 2 mating type loci MATa and MAT.alpha. each produce 2 mRNAs that are transcribed in opposite and diverging directions from central promoters. Silent copies of MATa (HMRa) and MAT.alpha. (HML.alpha.) contain identical DNA sequences throughout the transcribed region, yet are not transcribed. Sequences to the left of HMRa (and probably HML.alpha.) must somehow affect transcription initiated at the center of each locus 700-1400 base pairs away. A possible mechanism for this position effect is discussed.

引用

页码：244 / 250

页数：7

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