PHOTODYNAMIC THERAPY FOR THORACIC MALIGNANCIES

被引：10

作者：

PASS, HI

POGREBNIAK, H

机构：

[1] Surgery Branch, Thoracic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

来源：

SEMINARS IN SURGICAL ONCOLOGY | 1992年 / 8卷 / 04期

关键词：

EARLY STAGE LUNG CANCER; DYE LASER; PHOTOFRIN II; INTRAPLEURAL THERAPY;

D O I：

10.1002/ssu.2980080407

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Photodynamic therapy (PDT) is an experimental form of cancer therapy which employs photoactivation of a sensitizing chemical by light of a given wavelength via the production of toxic oxygen species. PDT causes local destruction of cancer, and relies on a therapeutic index between normal and malignant tissue since the latter seems to selectively retain the sensitizer. PDT has both direct tumoricidal effects as well as indirect effects on tumor vasculature causing an early hemorrhagic necrosis of tissue. The treatment has been used for the treatment of endobronchial obstruction by primary and metastatic tumors. Most recently, trials are being performed to evaluate this therapy as a surgical adjunct in the treatment of pleural malignancies such as mesothelioma.

引用

页码：217 / 225

页数：9

共 27 条

[1] Pass HI, Delaney T, Photodynamic therapy, Cancer: Principles and Practice of Oncology
[2] Dougherty TJ, Photosensitizers: Therapy and detection of malignant tumors, Photochem Photobiol, 45, pp. 874-882, (1987)
[3] Hayata Y, Kato H, Konaka C, Et al., Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer, Chest, 81, pp. 269-277, (1982)
[4] Pass HI, Evans S, Matthews WA, Et al., Photodynamic therapy of oncogene transformed cells, J Thorac Cardiovasc Surg, 101, pp. 795-799, (1991)
[5] Mitchell JG, McPherson S, DeGraff W, Et al., Oxygen dependence of hematoporphyrin derivative induced photoinactivation of Chinese hamster Cells, Cancer Res, 45, pp. 2008-2011, (1985)
[6] Pass HI, Delaney T, Smith PD, Et al., Bronchoscopic phototherapy at comparable dose rates: Early results, Ann Thorac Surg, 47, pp. 693-699, (1989)
[7] Pass HI, Reed CE, Lasers in the management of upper aerodigestive malignanciess, Important Advances in Oncology 1990, pp. 159-183, (1990)
[8] Kato H, Lung cancer, Lasers and Hematoporphyrin Derivative in Cancer, (1983)
[9] Kato H, Aizawa K, Ono J, Et al., Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, in a spectroscope, Laser Surg Med, 4, pp. 49-58, (1984)
[10] Edell ES, Cortese DA, Bronchoscopic phototherapy with hematoporphyrin derivative for treatment of localized bronchogenic carcinoma: A 5‐year experience, Mayo Clin Proc, 62, pp. 8-14, (1987)

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