DOUBLESTIMULI-RESPONSIVE DEGRADABLE HYDROGELS FOR DRUG-DELIVERY - INTERPENETRATING POLYMER NETWORKS COMPOSED OF OLIGOPEPTIDE-TERMINATED POLY(ETHYLENE GLYCOL) AND DEXTRAN

被引：25

作者：

KURISAWA, M

TERANO, M

YUI, N

机构：

[1] School of Materials Science, Japan Advanced Institute of Science and Technology, Tatsunokuchi, 923-12, 15, AsahidaiIshikawa

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 1995年 / 16卷 / 09期

关键词：

D O I：

10.1002/marc.1995.030160905

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Biodegradable hydrogels composed of oligopeptide-terminated poly(ethylene glycol) (PEG) and dextran with interpenetrating polymer network (IPN) structure were proposed as a novel substrate for multistimuli-responsive drug delivery. IPN-structured hydrogels were synthesized by sequential crosslinking reactions of N-methacryloyl-glycilglycilglycil-terminated PEG and dextran. In vitro degradation of the IPN-structured hydrogels was examined using papain and dextranase as model enzymes for hydrolyzing the oligopeptide and the dextran. Specific degradation in the presence of papain and dextranase was observed in the IPN-structured hydrogel with a particular composition of PEG and dextran, whereas this hydrogel was not degraded by one of the two enzymes.

引用

页码：663 / 666

页数：4

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