COMPARATIVE IN-VITRO ACTIVITIES OF NEW QUINOLONES AGAINST CORYNEFORM BACTERIA

The in vitro activities of eight quinolones against 115 coryneform bacteria (20 Corynebacterium jeikeium, 15 Corynebacterium minutissimum, 15 Corynebacterium striatum, 25 Corynebacterium urealyticum, 10 Corynebacterium xerosis, 10 Corynebacterium group ANF-1, 10 Corynebacterium group 12, and 10 Listeria monocytogenes) were determined. The MICs of ciprofloxacin, ofloxacin, and sparfloxacin for 90% of C. jeikeuim, C. urealyticum, and C. xerosis isolates tested were >16 mu g/ml. Those of BAY Y 3118 and clinafloxacin against these species were 0.5 and 1 to 2 mu g/ml, respectively. The MICs for 90% of all 115 strains tested were 0.5 mu g/ml for BAY Y 3118, 1 mu g/ml for clinafloxacin, 2 mu g/ml for E-5068, 4 mu g/ml for E-5065, and >16 mu g/ml for ciprofloxacin, ofloxacin, sparfloxacin, and E-4868.