THE HUMAN-IMMUNODEFICIENCY-VIRUS INTEGRASE PROTEIN

被引：104

作者：

VINK, C

PLASTERK, RHA

机构：

[1] C. Vink and R.H.A. Platerk are in the Division of Molecular Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam

来源：

TRENDS IN GENETICS | 1993年 / 9卷 / 12期

关键词：

D O I：

10.1016/0168-9525(93)90107-S

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The DNA integration step in the replication cycle of the human immunodeficiency virus (HIV) has been recognized as an important target in antiviral strategies. There are two main reasons for this. First, integration of HIV DNA into the human genome is required for replication of this retrovirus. Second, since the integration reaction does not have an obvious cellular counterpart, drugs that specifically inhibit integration may not be toxic for the cell. Here, we focus on the only protein known to be required for retroviral integration, the integrase (IN) protein.

引用

页码：433 / 437

页数：5

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