A POSSIBLE YEAST HOMOLOG OF HUMAN ACTIVE-GENE-REPAIRING HELICASE ERCC6

被引：8

作者：

HUANG, ME ^{[1
]}

CHUAT, JC ^{[1
]}

GALIBERT, F ^{[1
]}

机构：

[1] FAC MED RENNES, BIOCHEM & MOLEC BIOL LAB,CNRS,UPR 41, UNITE RECOMBINAISONS GENET, F-35043 RENNES, FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1703

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here the sequencing and identification on the chromosome X of S. cerevisiae of an open reading frame, designated GTA1085, encoding a protein 1085 amino acids in size that displays significant homology to a of helicase subfamily. The highest similarity score is with EXCC6, a human putative helicase involved in the repair of active genes, with 53.3 % identity over a stretch of 589 amino acids, This putative protein contains all seven consecutive domains conserved among DNA and RNA helicases. Thus, it apparently constitutes a novel member of this subfamily and might be involved, like EXCC6, in the preferential repair of active genes in yeast. (C) 1994 Academic Press, Inc.

引用

页码：310 / 317

页数：8

共 26 条

[1] IDENTIFICATION OF A SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE SNF2 TRANSCRIPTIONAL REGULATOR IN THE DNA-SEQUENCE OF AN 8.6 KB REGION IN THE LTE1-CYS1 INTERVAL ON THE LEFT ARM OF CHROMOSOME-I [J].