HUMAN SATELLITE CELL-PROLIFERATION IN-VITRO IS REGULATED BY AUTOCRINE SECRETION OF IL-6 STIMULATED BY A SOLUBLE FACTOR(S) RELEASED BY ACTIVATED MONOCYTES

被引：93

作者：

CANTINI, M ^{[1
]}

MASSIMINO, ML ^{[1
]}

RAPIZZI, E ^{[1
]}

ROSSINI, K ^{[1
]}

CATANI, C ^{[1
]}

DALLALIBERA, L ^{[1
]}

CARRARO, U ^{[1
]}

机构：

[1] UNIV PADUA,DEPT BIOMED SCI,NATL RES COUNCIL UNIT MUSCLE BIOL & PHYSIOPATHOL,I-35131 PADUA,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 216卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.2590

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We previously showed that macrophages, besides their scavenger role, selectively induce rat myoblast proliferation in vitro by releasing soluble factors. In this paper we demonstrate a relationship between human-activated monocytes and increased human myoblast proliferation due to IL-6 autocrine secretion by satellite cells. Indeed in the supernatants of muscle cultures treated with activated monocyte-conditioned medium we show by means of an ELISA quantitation a higher autocrine secretion of IL-6 associated with increased myoblast proliferation. This suggests that a growth factor(s) secreted by activated monocytes stimulates IL-6 production by myoblasts and then regulates proliferation of satellite cells. (C) 1995 Academic Press, Inc.

引用

页码：49 / 53

页数：5

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