CANCER - EXPLORING THE BOWELS OF DNA METHYLATION

被引：12

作者：

BALMAIN, A

机构：

[1] CRC Beatson Laboratories, Department of Medical Oncology, University of Glasgow, Garscube Estate, Bearsden

来源：

CURRENT BIOLOGY | 1995年 / 5卷 / 09期

关键词：

D O I：

10.1016/S0960-9822(95)00204-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies of mice lacking methyltransferase, and of genes that modify cancer susceptibility, have shed light on the long-standing problem of how DNA methylation affects carcinogenesis.

引用

页码：1013 / 1016

页数：4

共 33 条

[1] HIGH-LEVELS OF DENOVO METHYLATION AND ALTERED CHROMATIN STRUCTURE AT CPG ISLANDS IN CELL-LINES [J].

ANTEQUERA, F ;

BOYES, J ;

BIRD, A .

CELL, 1990, 62 (03) :503-514

[2] PARENTAL IMPRINTING OF THE MOUSE H19 GENE [J].

BARTOLOMEI, MS ;

ZEMEL, S ;

TILGHMAN, SM .

NATURE, 1991, 351 (6322) :153-155

[3] FUNCTIONS FOR DNA METHYLATION VERTEBRATES [J].

BIRD, AP .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1993, 58 :281-285

[4] RATES OF P16(MTS1) MUTATIONS IN PRIMARY TUMORS WITH 9P LOSS [J].

CAIRNS, P ;

MAO, L ;

MERLO, A ;

LEE, DJ ;

SCHWAB, D ;

EBY, Y ;

TOKINO, K ;

VANDERRIET, P ;

BLAUGRUND, JE ;

SIDRANSKY, D .

SCIENCE, 1994, 265 (5170) :415-416

[5] PARENTAL IMPRINTING OF THE MOUSE INSULIN-LIKE GROWTH FACTOR-II GENE [J].

DECHIARA, TM ;

ROBERTSON, EJ ;

EFSTRATIADIS, A .

CELL, 1991, 64 (04) :849-859

[6] GENETIC IDENTIFICATION OF MOM-1, A MAJOR MODIFIER LOCUS AFFECTING MIN-INDUCED INTESTINAL NEOPLASIA IN THE MOUSE [J].

DIETRICH, WF ;

LANDER, ES ;

SMITH, JS ;

MOSER, AR ;

GOULD, KA ;

LUONGO, C ;

BORENSTEIN, N ;

DOVE, W .

CELL, 1993, 75 (04) :631-639

[7] HYPOMETHYLATION DISTINGUISHES GENES OF SOME HUMAN CANCERS FROM THEIR NORMAL COUNTERPARTS [J].

FEINBERG, AP ;

VOGELSTEIN, B .

NATURE, 1983, 301 (5895) :89-92

[8] GENOMIC IMPRINTING AND GENE ACTIVATION IN CANCER [J].

FEINBERG, AP .

NATURE GENETICS, 1993, 4 (02) :110-113

[9] THE 5-METHYLCYTOSINE CONTENT OF DNA FROM HUMAN-TUMORS [J].

GAMASOSA, MA ;

SLAGEL, VA ;

TREWYN, RW ;

OXENHANDLER, R ;

KUO, KC ;

GEHRKE, CW ;

EHRLICH, M .

NUCLEIC ACIDS RESEARCH, 1983, 11 (19) :6883-6894

[10]

GREENBLATT MS, 1994, CANCER RES, V54, P4855

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