KINETIC STUDIES OF HYDRALAZINE REACTION WITH ACETALDEHYDE

被引：13

作者：

ODONNELL, JP ^{[1
]}

PROVEAUX, WJ ^{[1
]}

MA, JKH ^{[1
]}

机构：

[1] W VIRGINIA UNIV,SCH PHARM,MORGANTOWN,WV 26506

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 10期

关键词：

Acetaldehyde—reaction with hydralazine; kinetics; half‐life; therapeutic implications; Antihypertensive agents—hydralazine; reaction with acetaldehyde; Hydralazine—reaction with acetaldehyde; Kinetics—hydralazine reaction with acetaldehyde;

D O I：

10.1002/jps.2600681016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In vitro kinetic studies of the reaction of hydralazine with acetaldehyde at physiological concentrations and pH were conducted. This reaction, which leads to the formation of 3‐methyl‐S‐triazolo[3,4‐α]phthalazine, may occur in the plasma and may represent an alternative pathway for hydralazine metabolism. The reaction of hydralazine with acetaldehyde followed second‐order kinetics with an activation energy of 16.9 kcal/mole. At 37°, the half‐life of the reaction for a solution containing 2.3° of acetaldehyde/ml and 1° of hydralazine/ml was 4.5 hr. The rate increased with increasing acetaldehyde concentrations. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1256 / 1258

页数：3

共 13 条

[1] HEMODYNAMIC AND METABOLIC RESPONSES TO VASODILATOR THERAPY IN ACUTE MYOCARDIAL-INFARCTION [J].