SERIAL PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF ISCHEMIC BRAIN INJURY IN HUMANS

被引：66

作者：

FENSTERMACHER, MJ ^{[1
]}

NARAYANA, PA ^{[1
]}

机构：

[1] UNIV TEXAS,SCH MED,DEPT RADIOL,6431 FANNIN,ROOM 2132,HOUSTON,TX 77030

来源：

INVESTIGATIVE RADIOLOGY | 1990年 / 25卷 / 09期

关键词：

Brain; Ischemia; Proton magnetic resonance spectroscopy; Spatial localization;

D O I：

10.1097/00004424-199009000-00016

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Four patients were observed serially with 1H magnetic resonance spectroscopy (MRS) at times ranging from 3 days to 10 weeks after a documented ischemic event. Spectra were obtained from 8 cc volumes in infarcted regions and contralateral matched normal regions. Reproducible variations in a-acetyl aspartate (NAA), creatine + phosphocreatine (Cr + PCr), and the sequential changes in lactate and lipid resonances are related to the pathophysiology of stroke. A conspicuous lack of significant change in the choline (Cho) resonance with concomittant decrease in NAA and Cr + PCr is reported as a possible marker of ischemic injury. © Lippincott-Raven Publishers.

引用

页码：1034 / 1039

页数：6

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