ACUTE EFFECTS OF A SOMATOSTATIN ANALOG ON KIDNEY-FUNCTION IN TYPE-1 DIABETIC-PATIENTS

被引：45

作者：

PEDERSEN, MM

CHRISTENSEN, SE

CHRISTIANSEN, JS

PEDERSEN, EB

MOGENSEN, CE

ORSKOV, H

机构：

[1] Second University Clinic of Internal Medicine, Aarhus Kommunehospital, Aarhus Kommunehospital

[2] First University Clinic of Internal Medicine, Aarhus Kommunehospital, Aarhus

[3] Institute of Experimental Clinical Research, University of Aarhus, Aarhus Kommunehospital

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 04期

关键词：

Glucagon; Growth hormone; Kidney function; Somatostatin analogue; Type; 1; diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01394.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Suppression of growth hormone by means of somatostatin has been suggested as a possible adjunct therapy in Type 1 diabetes. To assess the acute effect of the somatostatin analogue SMS 201–995 on kidney function in uncomplicated Type 1 diabetes, 13 normoalbuminuric, normotensive diabetic patients were investigated before and during IV infusion of SMS 201–995 (8 μg h−1). A control experiment with infusion of carrier only was also performed. The SMS infusion induced a reduction in the glomerular filtration rate (clearance of 125I‐iothalamate) and renal plasma flow (131I‐hippuran) from 140 ± 15 (mean ± SD) and 550 ± 69 to 131 ± 14 (2p < 0.005) and 492 ± 73 ml min−1 1.73‐m−2 (2p < 0.001), while filtration fraction and total renal resistance rose (both 2p < 0.001). Urinary albumin excretion rate, blood pressure, and blood glucose concentration were unchanged. Plasma growth hormone and glucagon were significantly suppressed. The reduction in glomerular filtration rate and renal plasma flow correlated with the fall in glucagon concentration (r = 0.57, 2p = 0.04, and r = 0.63, 2p = 0.02). The urinary flow rate was markedly reduced, urine osmolality increased, and fractional excretion of sodium, calcium, and phosphate were reduced. Arginine vasopressin, atrial natriuretic peptide, angiotensin II, and aldosterone were unchanged by the SMS infusion. Thus SMS 201–995 acutely reduces glomerular filtration rate and renal plasma flow in uncomplicated Type 1 diabetes and has an antidiuretic effect. The effects may be related to suppression of glucagon secretion. 1990 Diabetes UK

引用

页码：304 / 309

页数：6

共 38 条

[1]

Lundbaek K., Jensen VA, Olsen TS, Et al., Diabetes, diabetic angiopathy, and growth hormone, Lancet, 2, pp. 131-133, (1970)

[2]

Johansen K., Hansen, Diurnal serum growth hormone levels in poorly and well‐controlled juvenile diabetics, Diabetes, 20, pp. 239-245, (1971)

[3]

Hansen, Normalization of growth hormone hyperresponse to exercise in juvenile diabetics after ‘normalization’ of blood sugar, J Clin Invest, 50, pp. 1806-1811, (1971)

[4]

Press M., Tamborlane WV, Sherwin RS., Importance of raised growth hormone levels in mediating the metabolic derangements of diabetes, N Engl J Med, 310, pp. 810-815, (1984)

[5]

Christensen NJ, Terkildsen AB., Quantitative measurements of skin capillary resistance in hypophysectomized long‐term diabetics, Diabetes, 20, pp. 297-301, (1971)

[6]

Ledet T., Growth hormone stimulating the growth of arterial medial cells in vitro. Absence of effect of insulin, Diabetes, 25, pp. 1011-1017, (1976)

[7]

Ledet T., Heickendorff L., Growth hormone effect on accumulation of arterial basement membrane‐like material studied on rabbit aortic myomedial cell cultures, Diabetologia, 28, pp. 922-927, (1985)

[8]

Mogensen CE., Kidney function and glomerular permeability to macromolecules in juvenile diabetes, Dan Med Bull, 19, pp. 1-36, (1972)

[9]

Christiansen JS, Gammelgaard J., Tronier B., Svendsen PA, Parving H-H., Kidney function and size in diabetics before and during initial insulin treatment, Kidney Int, 21, pp. 683-688, (1982)

[10]

Christiansen JS, Gammelgaard J., Frandsen M., Parving H-H., Increased kidney size, glomerular filtration rate and renal plasma flow in short‐term insulin‐dependent diabetics, Diabetologia, 20, pp. 451-456, (1981)

← 1 2 3 4 →