LUNG-FUNCTION IMPROVEMENT IN ASTHMA WITH A CYSTEINYL-LEUKOTRIENE RECEPTOR ANTAGONIST

被引：184

作者：

HUI, KP ^{[1
]}

BARNES, NC ^{[1
]}

机构：

[1] LONDON CHEST HOSP,DEPT THORAC MED,BONNER RD,LONDON E2 9JX,ENGLAND

来源：

LANCET | 1991年 / 337卷 / 8749期

关键词：

D O I：

10.1016/0140-6736(91)91709-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In a double-blind study ten asthmatic patients with impaired lung function received the cysteinyl-leukotriene receptor antagonist ICI 204,219 (40 mg by mouth) and placebo in random order on 2 days at least 1 week apart. The increase in forced expiratory volume in 1 s (FEV1) above baseline was significantly greater after ICI 204,219 than after placebo. This effect persisted after nebulised salbutamol. These findings suggest that cysteinyl-leukotrienes are one of the causes of persistent bronchoconstriction in chronic asthma.

引用

页码：1062 / 1063

页数：2

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