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NC37-R1 EPSTEIN-BARR VIRUS (EBV) - POSSIBLE RECOMBINANT BETWEEN INTRACELLULAR NC37 VIRAL-DNA AND SUPERINFECTING P3HR-1 EBV

被引：25
作者：
FRESEN, KO
CHO, MS
GISSMANN, L
ZURHAUSEN, H
机构：
[1] Institut für Virologie, Zentrum für Hygiene, Universität Freiburg, Freiburg i. Br
来源：
INTERVIROLOGY | 1979年 / 12卷 / 06期
关键词：
Blot hybridization; NC37; cells; NC37-RI EBV; Recombinant; Rescued virus; Transformation;
D O I：
10.1159/000149089
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The NC37-RI cell line, established after transformation of human cord blood lymphocytes with Epstein-Barr virus (EBV) recovered from P3HR-1 superinfected NC37 cells, spontaneously produces viral particles with transforming but without early antigen-inducing properties. Progeny virus of NC37-RI has retained its biological characteristics of spontaneous virus release and transformation up to four cycles of transformation at present. Analysis of purified NC37-RI virion DNA, after cleavage with restriction endonuclease Hind III and comparison of its fragments with P3HR-1 EBV as well as intracellular NC37 viral DNA using the blot hybridization technique, suggests that NC37-R1 originates from a recombination between super-infecting P3HR-1 and endogenous NC37 EBV DNA. © 1979 S. Karger AG, Basel.
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页码：303 / 310
页数：8
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