SUGAR MODIFIED OLIGONUCLEOTIDES - SYNTHESIS, NUCLEASE RESISTANCE AND BASE-PAIRING OF OLIGODEOXYNUCLEOTIDES CONTAINING 1-(4'-THIO-BETA-D-RIBOFURANOSYL)-THYMINE

被引：17

作者：

BELLON, L

MORVAN, F

BARASCUT, JL

IMBACH, JL

机构：

[1] Université de Montpellier II Sciences et Techniques du Languedoc, Laboratoire de Chimie Bio-Organique, URA 488 du CNRS, 34095 Montpellier cédex 5, Place E. Bataillon

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 184卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90660-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

XdT12 and dT5XdT6, where X is 1-(4′-thio-β-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one. © 1992.

引用

页码：797 / 803

页数：7

共 19 条

[1] INHIBITION OF VESICULAR STOMATITIS-VIRUS PROTEIN-SYNTHESIS AND INFECTION BY SEQUENCE-SPECIFIC OLIGODEOXYRIBONUCLEOSIDE METHYLPHOSPHONATES
AGRIS, CH
BLAKE, KR
MILLER, PS
REDDY, MP
TSO, POP
[J]. BIOCHEMISTRY, 1986, 25 (20) : 6268 - 6275
[2] BELLON L, 1991, UNPUB NUCLEOSIDES NU
[3] HYBRIDIZATION ARREST OF GLOBIN-SYNTHESIS IN RABBIT RETICULOCYTE LYSATES AND CELLS BY OLIGODEOXYRIBONUCLEOSIDE METHYLPHOSPHONATES
BLAKE, KR
MURAKAMI, A
SPITZ, SA
GLAVE, SA
REDDY, MP
TSO, POP
MILLER, PS
[J]. BIOCHEMISTRY, 1985, 24 (22) : 6139 - 6145
[4] SUGAR MODIFIED OLIGONUCLEOTIDES .2. SOLID-PHASE SYNTHESIS OF NUCLEASE RESISTANT ALPHA-ANOMERIC URIDYLATES AS POTENTIAL ANTISENSE AGENTS
DEBART, F
RAYNER, B
IMBACH, JL
[J]. TETRAHEDRON LETTERS, 1990, 31 (25) : 3537 - 3540
[5] NUCLEOSIDE PHOSPHOROTHIOATES
ECKSTEIN, F
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1985, 54 : 367 - 402
[6] SUGAR-MODIFIED OLIGONUCLEOTIDES - SYNTHESIS, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
IMBACH, JL
RAYNER, B
MORVAN, F
[J]. NUCLEOSIDES & NUCLEOTIDES, 1989, 8 (5-6): : 627 - 648
[7] STUDIES ON NUCLEIC-ACID INTERACTIONS .1. STABILITIES OF MINI-DUPLEXES (DG2A4XA4G2.DC2T4YT4C2) AND SELF-COMPLEMENTARY D(GGGAAXYTTCCC) CONTAINING DEOXYINOSINE AND OTHER MISMATCHED BASES
KAWASE, Y
IWAI, S
INOUE, H
MIURA, K
OHTSUKA, E
[J]. NUCLEIC ACIDS RESEARCH, 1986, 14 (19) : 7727 - 7736
[8] PREPARATION OF OLIGODEOXYRIBONUCLEOSIDE METHYLPHOSPHONATES ON A POLYSTYRENE SUPPORT
MILLER, PS
AGRIS, CH
MURAKAMI, A
REDDY, PM
SPITZ, SA
TSO, POP
[J]. NUCLEIC ACIDS RESEARCH, 1983, 11 (18) : 6225 - 6242
[9] MILLER PS, 1986, MOL MECHANISMS CARCI, P169
[10] ALPHA-DNA-II - SYNTHESIS OF UNNATURAL ALPHA-ANOMERIC OLIGODEOXYRIBONUCLEOTIDES CONTAINING THE 4 USUAL BASES AND STUDY OF THEIR SUBSTRATE ACTIVITIES FOR NUCLEASES
MORVAN, F
RAYNER, B
IMBACH, JL
THENET, S
BERTRAND, JR
PAOLETTI, J
MALVY, C
PAOLETTI, C
[J]. NUCLEIC ACIDS RESEARCH, 1987, 15 (08) : 3421 - 3437

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