HPLC ANALYSIS OF NOVEL ANTICANCER AGENTS-ILLUDINS AND THEIR ANALOGS

被引：5

作者：

BRANDSTETEROVA, E

KELNER, MJ

MCMORRIS, TC

WANG, W

BANGELL, R

机构：

[1] SLOVAK UNIV TECHNOL BRATISLAVA, DEPT PATHOL, CS-81237 BRATISLAVA, CZECHOSLOVAKIA

[2] UNIV CALIF SAN DIEGO, DEPT CHEM, SAN DIEGO, CA 92103 USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1080/10826079308020901

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

High performance liquid chromatography combined with liquid extraction and solid-phase extraction were used for determining the serum concentration of new anticancer drugs. Extraction recoveries were evaluated for wide range of concentrations in serum. Adsorption and reversed-phase chromatographic modes were tested for the separation and drugs determination in model mixtures and actual clinical samples. The HPLC assay developed was applied for farmacokinetic studies of acylfulvene in dog and rats.

引用

页码：115 / 125

页数：11

共 8 条

[1] ANTIBIOTIC SUBSTANCES FROM BASIDIOMYCETES .7. CLITOCYBE ILLUDENS [J].