NUCLEOTIDE-SEQUENCE OF THE HERPES-SIMPLEX VIRUS TYPE-2 GENE ENCODING THE PROTEASE AND CAPSID PROTEIN ICP35

被引：12

作者：

STEFFY, KR

SCHOEN, S

CHEN, CM

机构：

[1] Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064, One Abbott Park Road

来源：

JOURNAL OF GENERAL VIROLOGY | 1995年 / 76卷

关键词：

D O I：

10.1099/0022-1317-76-4-1069

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The complete nucleotide sequence of the gene encoding the protease and ICP35 capsid protein of herpes simplex virus (HSV) type 2 strain G has been determined. The gene consisits of a 1908 bp open reading frame capable of encoding 636 amino acids. Comparative nucleotide sequence analysis of the gene with published HSV-1 sequences revealed that the HSV-2 nucleic acid segment most likely encodes two distinct proteins. The first protein is the HSV-2 protease, which is required for the assembly of the herpes virus capsid. The second protein has been previously designated as ICP35 in HSV-1, and belongs to the family of herpesvirus capsid proteins.

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页码：1069 / 1072

页数：4

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