HYDROXAMIC ACIDS .I. FACTORS AFFECTING STABILITY OF HYDROXAMIC ACID-IRON COMPLEX

被引：44

作者：

NOTARI, RE

MUNSON, JW

机构：

[1] College of Pharmacy, The Ohio State University, Columbus, Ohio

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Colorimetric analysis–spectrophotometer; Hydroxamic acid‐iron complex–stability; Stability; hydroxamic acid‐iron complex–factors affecting; Succinimide analysis–hydroxamic acid‐iron complex;

D O I：

10.1002/jps.2600580904

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The utility of hydroxamic acid formation and subsequent iron complexation as an analytical tool for succinimide has been investigated. Several factors affecting the stability of the hydroxamic acid‐ferric iron complex have been studied and critical factors in the stability of the complex have been established. Conditions for a stable complex are reported. An assay utilizing hydroxamic acid formation from succinimide has been developed and shown to be completely reproducible. Two hydroxamic acids, acetohydroxamic acid and N‐hydroxysuccinamide, are shown to give stable color complexes under the recommended conditions. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1060 / &

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